Around and in the Laboratory
Examination of (bio)-degradability of chemicals and pharmaceuticals
according to OECD/DIN/ISO and others:
- Closed Bottle-Test (OECD 301 D)
- Manometric Respirometry (OECD 301 F)
- Zahn-Wellens-Test (OECD 302 B)
- Waste water treatment plant simulation (OECD 303 A)
- Water Sediment Test (according to OECD)
- anaerobic degradation testing (according to DIN EN ISO 117341)
- Photodegradation
- UV light
- sun light
- photocatalysis
Toxicity in bacteria and algae:
- modified luminescent bacteria test with Vibrio fischeri
- Cell multiplication inhibition test with Pseudomonas putida and Escherichia coli
- Long-term contact test with Pseudomonas putida and Bacillus amyloliquefaciens
- algae toxicity
- Ames-Test with Salmonella typhimurium TA 98/TA 100
- Umu-Test with Salmonella typhimurium TA 1535/ psK 1002
- Mikronucleus-Test with CHO-Cells by FACS-Analysis
Structure property relationships (QSAR), also in REACH-Quality
- Calculation of physicochemical properties of molecules
- Calculation of quantum chemical parameters of molecules
- Calculation of toxicity and eco-toxicity
- Calculation of mutagenicity according to ICHM7 in U.S. FDA/EMA-approved quality
- Calculation of the biological degradation
- Predictions for metabolites and degradation products (mammalia, bacteria, light)
Docking
- prediction of pharmaceutical effects, in combination with QSAR (drug likeness)
Material transport modelling and assessment
- Spatio-temporal analysis of discharge and water quality (R-Statistics, SigmaPlot, ArcGIS)
- Assessment of water quality by combined water quality and quantity indices (WQI, WQQI, WAI)
- Water quality modelling in lakes and reservoirs in 1D, 2D and 3D (LAC, MOHID Water, Ce-qual)
- Catchment modelling of hydrology, erosion and sedimenttransport, phosphorus discharge, pesticides and transformation product discharge (ZIN-Sed, MOHID Land, reservoir models)
- River channel modelling of water, sediment, phosphorus, pesticide and transformation products discharge (ZIN-Sed, MOHID Stream)
- Scenario modelling and assessment
- System analysis and management assessment
- Integrated water resources management
- LC-MS/MS (Liquid chromatography coupled to ion trap mass spectrometry and
- high-resolution mass spectrometry (Orbitrap)
- low resolutionary (Ion Trap, Triple Quad)
- NMR Spinsolve Carbon (Magritek) mit 42,5 MHz 1H und 10,8 MHz 13C
- HPLC with UV and fluorescence detection
- Gas chromatography coupled to mass spectrometry
- Ion chromatography
- IR Spectrometers
- UV Spectrometers
